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CD314, also known as NKG2D, is a 42 kDa type II transmembrane protein belonging to the C-type lectin superfamily. The name NKG2D may be misleading as it is not a typical NKG2 family member. It has low homology with the other members and dimerizes with itself to form a homodimer while other members dimerize with CD94. The surface expression of NKG2D requires association with a signaling adaptor protein, a KAP10 (DAP10) homodimer that contains a Y-x-x-M motif. Upon tyrosine phosphorylation, that motif recruits and activates phosphatidylinositol 3’ (PI 3)-kinase. Unlike natural cytotoxicity receptors (NCRs), NKG2D is not only expressed by all NK cells but also by most γδ T cells and by virtually all CD8+αβ T cells. In addition, its expression can be up-regulated on NK cells by different cytokines (IL-15, IL -12 and IFN-γ). Human CD314 ligands identified so far are MICA and MICB, stress-inducible and broadly expressed molecules on tumors of epithelial origin, some melanomas, and ULBPs, targets of the human CMV protein, expressed on a wide range of cells. NKG2D triggering would appear to overrule the inhibitory signals delivered by the KIR and HLA class 1 interactions. NKG2D might play a complementary role in the NK-cell mediated lysis of target cells that appear to express HLA class I molecules normally and that express one or more NKG2D-specific ligands.
Isotype: IgG1 Mouse
The ON72 antibody has been used in flow cytometry to analyze the expression of NKG2D on NK cells.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
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