CD40 Antigen

The CD40 antigen is a 44-48 kDa type I integral membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. This antigen is found on B cell lines, is strongly expressed by interdigitating cells (IDC), basal epithelial cells, and is also present on macrophages, some endothelial cells, and follicular dendritic cells. It is a pan-B marker, absent only from terminally differentiated plasma cells. CD40 is implicated in the process of B cell selection in the germinal centre. Studies demonstrated that CD40 monoclonal antibodies (mAbs) induce strong homotypic adhesions in resting B cells and, together with interleukin-4 (IL-4) maintain the cell cycle of blasts of the B lineage. They also can promote the switch to IgE secretion. Activated B cells via CD40 antigen in the presence of IL-10 differentiate into plasma cells and secrete large amounts of immunoglobulins. The CD154, (CD40 ligand) is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin secretion. CD154 is also expressed on activated platelets and triggers an inflammatory reaction of endothelial cells.


 Clone: MAB89   Isotype: IgG1 Mouse

Co-culture with MAB89 and IL-4 leads to long term B cell proliferation.
 

Choose a CD40 Model

Product Line Specifications

Format Liquid
Specificity CD40
Form APC
Clone MAB89
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B30636

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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