Vaccine & Therapy Development
Solutions for each step of the process of vaccine and therapy development, from isolation and purification of biological molecules to development of cell lines to screening of drugs and efficacy/dosing studies.Vaccine & Therapy Development Workflows
Plasmid Purification
High-resolution purification of plasmids for transfection and therapeutic vectors with Optima X Series benchtop and floor ultracentrifuges.
Cell Line Development
Development of stable or transient cell lines for the production of purified antigens using 21 CFR Part 11-supported Biomek i-Series automated liquid handlers.
Antibody Construction
Synthetic antibody construction by miniaturizing isothermal DNA assembly using the Echo 525.
Antibody Engineering
Antibody engineering using hybridoma based technology to make antibodies and evaluate their specificity with ELISAs using an end-to-end Biomek i-Series-based system.
Media Monitoring
Optimize and monitor media conditions and viable cell density for maximum product yield using the Vi-CELL BLU and Vi-CELL MetaFLEX.
Dose Response Assays
Dose response assays for assessing the effects of candidate compounds on multiple endpoints simultaneously, such as cell viability, apoptosis, and proliferation. The 96-well plate loader on the CytoFLEX flow cytometer as well as the built-in heat map tool on the software enables efficient data analysis.
Synergistic Dose Response Assays
Synergistic dose response assays for combinatorial drug repurposing using the Echo Combination Screen application on the Echo 650R.
Targeted Killing Assays
Targeted killing assays can be performed with flow cytometry to quantify the efficiency of target cell elimination. The 96-well plate loader on the CytoFLEX flow cytometer as well as the built-in heat map tool on the software enables efficient data analysis.
Infection Detection
Cell transduction and/or target-cell infection detection based on changes in the cell volume identified using the Multisizer 4e.