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The CD13 antigen is a transmembrane glycoprotein with a large extracellular region and a small intracellular NH2-terminal tail. It has a molecular weight of 150 kDa and is expressed on the cell surface as a non-covalently linked homodimer. It is found on most cells of myeloid origin including neutrophils, eosinophils, basophils and monocytes from normal peripheral blood. It is absent from B and T lymphocytes as well as from red blood cells and platelets. This molecule is found on the surface of committed progenitor cells defined as the Granulocyte-Monocyte Colony Forming Units (CFU-GM) in normal bone marrow. There are up to five subpopulations of CD13 molecules possessing different levels of glycosylation, which may explain the different binding patterns of various CD13 antibodies.
Aminopeptidase N, APN, CD13, EC 126.96.36.199, gp150
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