Some features of beckman.com will be unavailable from 8:00 p.m. PDT Saturday, December 7 until 12:00 a.m. PDT, Sunday, December 8 for planned maintenance. During this time, you will not be able to log in to use account features such as online shopping, shopping lists and order tracking.
Please ensure your orders are processed prior to this maintenance period or contact Client Services for additional assistance.
The CD160 molecule (BY55 antigen) is a 27-kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of 181 amino acids, with a single immunoglobulin (Ig)-like domain. The molecule contains two potential sites for N-glycosylation and is rich in cysteine (6 residues in the mature polypeptide), indicating an important capacity for forming intra- and inter-chain disulfide bonds, which likely support the disulfide-linked multimeric (80 kDa) expression at the cell surface. Its expression is highly restricted to circulating cytotoxic T and NK cells, and in tissues, to intestinal intraepithelial lymphocytes, as revealed by CD160 mRNA blot analysis and various phenotyping studies. In peripheral blood, CD160+ cells consist of a majority of CD3– TCRγδ+ NK cells, which is significantly reduced in HIV+ individuals, and of a minority of CD3+ CD8bright T lymphocytes, which is significantly increased in HIV+ individuals. In bone marrow, CD160+ cells, though less abundant than in adult peripheral blood, also consist of the two populations observed in peripheral blood. In cord blood, CD160+ cells consist of a unique CD3– TCR– NK cell population, 80% of these cells being CD56+. CD160 is a ligand for classical and non-classical MHC-class I molecules. The ligation of MHC-class I by CD160 provides a costimulatory signal restricted to peripheral blood activated T cells, suggesting a pathway being additional and/or alternative to the CD28 costimulation mechanism. This pathway may be relevant in memory T cells that lack CD28, such as the intestinal intraepithelial lymphocytes.
BY55, CD160, NK1, NK28
Flow Product Line
The BY55 antibody was initially reported to react with a protein structure of 80 kDa exclusively expressed by circulating cytotoxic lymphocytes. It does not block the binding of the CD160 molecule to MHC-class I molecules.
Related Products or Parts
Customers Also Viewed
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS
The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.