Some features of beckman.com will be unavailable from 8:00 p.m. PDT Saturday, December 7 until 12:00 a.m. PDT, Sunday, December 8 for planned maintenance. During this time, you will not be able to log in to use account features such as online shopping, shopping lists and order tracking.
Please ensure your orders are processed prior to this maintenance period or contact Client Services for additional assistance.
Tumor necrosis factor α (TNFα) or cachectin is a cytokine that was first identified based on its cytotoxic activity against various cell lines and tumor cells. Human TNFα is synthesized as a pro-protein with a molecular weight of 26 kDa (membrane-bound form). The pro-protein is cleaved by a specific metalloprotease (TACE) yielding a monomeric, soluble form of 17 kDa. Under physiological conditions, TNFα forms a homotrimeric protein. This cytokine is primarily produced by mononuclear phagocytes, and by activated lymphocytes. Immunostaining allows intracellular detection of TNFα before it can be detected by a bioassay. TNFα acts on target cells by binding to two types of receptors, the TNFα receptor I (TNF-RI or CD120a) and the TNFα receptor II (TNF-RII or CD120b). TNFα elicits a wide spectrum of immune and inflammatory responses, including the induction of other cytokines and immunoregulatory molecules, cell growth and differentiation and apoptosis. This molecule is also involved in Th1 - Th2 (T helper 1 - T helper 2) cytokine pathways (or Type 1 - Type 2 responses), as a Th1-effector cytokine.
Especificações
Target Species
Human
Specificity
TNFα
Fluorochrome
PE
Regulatory Status
ASR
Size
2 mL
Format
Liquid
Flow Product Line
IOTest
Clone
IPM2
Isotype
IgG1 Mouse
Related Products or Parts
Customers Also Viewed
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS
The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.