Beckman.com is conducting maintenance Saturday, September 19th and Sunday, September 20th. Parts of the site may have limited accessibility throughout the weekend. During this time, orders can still be placed by calling Client Services. We look forward to providing an improved customer experience. Beckman.com will return Monday, September 21st.
Chimeric antigen receptors (CARs) are synthetically engineered recombinant receptors. In T cells, they represent a single receptor capable of facilitating both antigen binding/recognition and T cell activation.1 Incorporating both of these signals into a single receptor reduces the number of interactions required for T cell activation and prevents cancer cells from exploiting single signal-based T cell inactivation mechanisms.
1. M. Sadelain, et al., “The basic principles of chimeric antigen receptor design,” Cancer Discov 3(4):388-398, 2013.
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